Peripheral Nerve Disorders

Your peripheral nerves are the ones outside your brain and spinal cord. Like static on a telephone line, peripheral nerve disorders distort or interrupt the messages between the brain and the rest of the body.

There are more than 100 kinds of peripheral nerve disorders. They can affect one nerve or many nerves. Some are the result of other diseases, like diabetic nerve problems. Others, like Guillain-Barre syndrome, happen after a virus infection. Still others are from nerve compression, like carpal tunnel syndrome or thoracic outlet syndrome. In some cases, like complex regional pain syndrome and brachial plexus injuries, the problem begins after an injury. Some people are born with peripheral nerve disorders.

Symptoms often start gradually, and then get worse. They include

  • Numbness
  • Pain
  • Burning or tingling
  • Muscle weakness
  • Sensitivity to touch

Treatment aims to treat any underlying problem, reduce pain and control symptoms.

NIH: National Institute of Neurological Disorders and Stroke

Different Conditions

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Related ICD 10 COde
ICD 10 Code G50.8

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Signs And Symptoms

  • Abnormal reflex (finding)
  • Abbreviated Terms

  • hyporeflexia
  • motor disorder
  • reflex disorder
  • motor disturbance
  • reflex disturbance
  • hyperreflexia
  • areflexia
  • Related ICD 10 COde
    ICD 10 Code R29.2

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    Benign neoplasm of cranial nerves

    Vestibular schwannoma is a rare tumor of the posterior fossa originating in the Schwann cells of the vestibular transitional zone of the vestibulocochlear nerve that can be benign, small, slow growing and asymptomatic or large, faster growing and aggressive and potentially fatal, presenting with symptoms of hearing and balance impairment, vertigo, ataxia, headache and fifth, sixth or seventh cranial nerve dysfunction and facial numbness.

    Abbreviated Terms

  • acoustic neurinoma
  • acoustic schwannoma
  • acoustic neurilemmoma
  • benign neoplasm of acoustic nerve
  • Related ICD 10 COde
    ICD 10 Code D33.3

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    Benign neoplasm of digestive organs

    A non-metastasizing neoplasm arising from the pancreas.

    Organ Affected

    Entire pancreas (body structure)|Pancreatic structure (body structure)

    Causes

    Neoplasm, benign (morphologic abnormality)

    Abbreviated Terms

  • benign neoplasm of body of pancreas
  • benign neoplasm of head of pancreas
  • benign neoplasm of pancreatic duct
  • benign neoplasm of tail of pancreas
  • benign tumour of body of pancreas
  • benign tumour of head of pancreas
  • benign tumour of pancreatic duct
  • benign tumour of tail of pancreas
  • Also Known As

  • benign pancreatic neoplasm
  • benign tumour of pancreas
  • Related ICD 10 COde
    ICD 10 Code D13.6

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    Abbreviated Terms

  • benign neoplasm of the nerve
  • ganglioneuromatosis
  • Related ICD 10 COde
    ICD 10 Code D36.1

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    Related ICD 10 COde
    ICD 10 Code D13.6

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    Related ICD 10 COde
    ICD 10 Code D36.1

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    Also Known As

  • Neurilemmoma of peripheral nerve
  • Benign nerve sheath tumour
  • Related ICD 10 COde
    ICD 10 Code D36.1

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    Birth injury to peripheral nervous system

    Birth injury to laryngeal nerve resulting in disturbance of breathing and/or swallowing. Vocal cord paralysis is the dominant feature.
    Related ICD 10 COde
    ICD 10 Code P14

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    Birth injury

    A condition characterized by the presence of damage to the nerves and ganglia outside of the brain and spinal cord due to physical pressure or injury during delivery.

    Organ Affected

    Peripheral nervous system structure (body structure)

    Causes

    Birth (finding)

    Abbreviated Terms

  • nerve paralysis, birth injury
  • paralysis, birth injury
  • Also Known As

  • peripheral nerve injury due to birth trauma
  • laceration of peripheral nerve, birth injury
  • injury of peripheral nerve, birth injury
  • Related ICD 10 COde
    ICD 10 Code P14

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    Brachial plexus palsy in newborn

    Erb paralysis is one of the most common brachial plexus birth palsy. The injury occurs in the upper brachial plexus nerves and affects the upper arm.

    Organ Affected

    Brachial plexus structure (body structure)|Entire brachial plexus (body structure)

    Causes

    Birth (finding)

    Abbreviated Terms

  • Erb paralysis due to birth injury
  • Erb-Duchenne paralysis
  • Also Known As

  • Duchenne paralysis, birth injury
  • Erb palsy as birth trauma
  • Erb-Duchenne palsy as birth trauma
  • erb palsy or paralysis, due to birth trauma
  • brachial plexus palsy limited to C5-C6, birth injury
  • Erb palsy
  • Related ICD 10 COde
    ICD 10 Code P14.0

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    Related ICD 10 COde
    ICD 10 Code G56.1

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    Related ICD 10 COde
    ICD 10 Code G54

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    Related ICD 10 COde
    ICD 10 Code G58

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    Related ICD 10 COde
    ICD 10 Code G54.8

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    Related ICD 10 COde
    ICD 10 Code G61

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    Abbreviated Terms

  • Cerebral anoxia due to anaesthesia during labour and delivery
  • central nervous system complications of sedation during labour and delivery
  • Related ICD 10 COde
    ICD 10 Code O74.3

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    Abbreviated Terms

  • Cerebral anoxia due to anaesthesia during the puerperium
  • Related ICD 10 COde
    ICD 10 Code O89.2

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    Disorders of cranial nerves

    The trigeminal nerve is a mixed nerve with three divisions, ophthalmic, maxillary and mandibular divisions, that provides sensory innervation to the face and mucous membrane of the oral and nasal cavities and motor innervations to the muscle of mastication, tensor tympani, tensor veli palatine, mylohyoid and anterior belly of the digastric muscle. The trigeminal nuclear complex extends throughout the brainstem, hence it is susceptible to many pathologic processes including demyelination, ischemia, hemorrhage, infectious and non-infectious inflammation and neoplasm leading to symptoms of trigeminal nerve involvement. Compression of the sensory nerve root outside the brain stem by a vascular loop leads to trigeminal neuralgia. Symptoms and signs depend on the site of the lesion. In general, a trigeminal nerve disorder is associated with hemisensory facial loss, deviation of the jaw to paralyzed side on opening of the mouth, and loss of the corneal reflex.

    Organ Affected

    Trigeminal nerve structure (body structure)

    Also Known As

  • Disorders of 5th cranial nerve
  • disorders of the fifth cranial nerve
  • Related ICD 10 COde
    ICD 10 Code G50

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    Related ICD 10 COde
    ICD 10 Code G52.1

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    Related ICD 10 COde
    ICD 10 Code G52.3

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    Disorders of nerve root, plexus or peripheral nerves

    These are conditions of the root and/or plexus portions of nerves. Plexus portions are network-like.

    Organ Affected

    Structure of nerve plexus (body structure)|Nerve root structure (body structure)
    Related ICD 10 COde
    ICD 10 Code G54

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    Related ICD 10 COde
    ICD 10 Code G52.0

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    Disorders of peroxisomal alpha-, beta- or omega-oxidation

    Refsum disease, a very rare disease, biochemically characterised by phytanic acid accumulation, belongs to the group of leukodystrophic diseases. The first symptom is hemeralopia (loss of vision in the dark), followed by episods of chronic distal motor polyneuropathy. Other associated signs include perceptive deafness, anosmia, cerebellous ataxia and sometimes, severe intellectual deficiency.

    Additional Information

    Refsum disease, biochemically characterised by phytanic acid accumulation, belongs to the group of leucodystrophic diseases. Prevalence of the disease is of 1 case per 1 000 000 and males and females are equally affected. Initial signs usually appear around the age of 15, but they can also manifest during childhood or at the age of 30-40 years. The first symptom is hemeralopia (loss of vision in the dark), followed by episods of chronic distal motor polyneuropathy. Other associated signs include perceptive deafness, anosmia, cerebellous ataxia and sometimes, severe intellectual deficiency. Over the course of time cutaneous signs appear (ichtyosis), along with polyepiphyseal dysplasia, myocardiopathy, elevated protein in cerebrospinal fluid, and pigmentary retinitis that may result in blindness. Refsum disease is transmitted as an autosomal recessive trait. This disorder results from phytanic acid (3,7,11,15-tetramethylhexadecanoic acid) accumulation, which leads to lesions essentially in retina, brain and peripheral nervous system. In most cases, the causative mutation is in the PHYH gene (or PAXH, localised in 10pter-p11.2) encoding the peroxysomal enzyme phytanoyl-CoA hydroxylase (PhyH), which alpha-oxidises phytanic acid and allows the first step of its degradation. Another mutation was recently identified in PEX7 gene, localised in 6q22-24. It codes for the peroxine 7 receptor, which allows the import of PhyH in peroxysomes. Diagnosis is brought by the biologic evidence of phytanic acid in plasma and urines. Heterozygotes can be detected. As phytanic acid comes exclusively from food (green vegetables and herbivore animals), a strict diet helps symptoms regress partly. Nevertheless, altered audition and vision as well as anosmia can persist.

    Organ Affected

    Nerve structure (body structure)|Entire nerve (body structure)

    Causes

    defective oxydation of phytanic acid

    Also Known As

  • Hereditary motor and sensory neuropathy type 4
  • Phytanic acid oxidase deficiency
  • Phytanic acid storage disease
  • Heredoataxia hemeralopica polyneuritiformis
  • Refsum-Thiebaut disease
  • HMSN 4 - [Hereditary motor and sensory neuropathy type 4]
  • Related ICD 10 COde
    ICD 10 Code G60.1

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    Related ICD 10 COde
    ICD 10 Code G50.8

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    Related ICD 10 COde
    ICD 10 Code G52.2

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    Abbreviated Terms

  • Hyperpathia
  • Related ICD 10 COde
    ICD 10 Code R20

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    Enthesopathies of lower limb

    This is a condition characterized by pain and inflammation in the ball of your foot or at the metatarsal heads.

    Signs And Symptoms

  • Pain (finding)
  • Organ Affected

    Metatarsal bone structure (body structure)|Entire metatarsal (body structure)

    Also Known As

  • metatarsalgia, unspecified foot
  • metatarsalgia NOS
  • Related ICD 10 COde
    ICD 10 Code M77.4

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    Erb paralysis

    Brachial plexus birth palsy that occurs when the nerve is torn but not from the spine
    Related ICD 10 COde
    ICD 10 Code P14.0

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    Related ICD 10 COde
    ICD 10 Code D36.1

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    Related ICD 10 COde
    ICD 10 Code G60

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    Related ICD 10 COde
    ICD 10 Code G60.3

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    Inflammatory polyneuropathy

    Subacute inflammatory demyelinating polyneuropathy (SIDP) is a subacute progressive symmetric sensorial and/or motor disorder characterized by muscular weakness with impaired sensation, absent or diminished tendon reflexes and elevated cerebrospinal fluid (CSF) proteins. SIDP is an intermediate form between Guillain-Barr???? syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP).
    Related ICD 10 COde
    ICD 10 Code G61

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    Related ICD 10 COde
    ICD 10 Code S35

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    Related ICD 10 COde
    ICD 10 Code S94

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    Related ICD 10 COde
    ICD 10 Code S54

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    Related ICD 10 COde
    ICD 10 Code S04

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    Related ICD 10 COde
    ICD 10 Code S74

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    Related ICD 10 COde
    ICD 10 Code S84

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    Related ICD 10 COde
    ICD 10 Code S44

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    Related ICD 10 COde
    ICD 10 Code S64

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    Abbreviated Terms

  • inferior mesenteric artery injury
  • injury of superior mesenteric artery
  • mesentery artery injury
  • superior mesentery artery injury
  • injury of inferior mesenteric artery
  • Related ICD 10 COde
    ICD 10 Code S35

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    Related ICD 10 COde
    ICD 10 Code S65.0

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    Also Known As

  • injury of tenth cranial nerve
  • Related ICD 10 COde
    ICD 10 Code S04

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    Abbreviated Terms

  • incomplete transection of mesenteric artery
  • laceration of mesenteric artery NOS
  • superficial laceration of mesenteric artery
  • Related ICD 10 COde
    ICD 10 Code S35

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    Abbreviated Terms

  • Injury of nerve root of lumbosacral spine
  • Related ICD 10 COde
    ICD 10 Code S34.2

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    Also Known As

  • injury of n.plantaris lateralis
  • Related ICD 10 COde
    ICD 10 Code S94.0

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    Abbreviated Terms

  • injury of ulnar nerve NOS
  • Related ICD 10 COde
    ICD 10 Code S54.0

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    Abbreviated Terms

  • injury of sciatic nerve
  • Related ICD 10 COde
    ICD 10 Code S74.0

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    Abbreviated Terms

  • injury of tibial nerve
  • Related ICD 10 COde
    ICD 10 Code S84.0

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    Also Known As

  • cervical nerve root injury
  • injury to cervical nerve root
  • Related ICD 10 COde
    ICD 10 Code S14.2

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    Related ICD 10 COde
    ICD 10 Code S44.0

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    Also Known As

  • injury of thoracic nerve root
  • Related ICD 10 COde
    ICD 10 Code S24.2

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    Abbreviated Terms

  • injury of ulnar nerve of hand
  • injury of ulnar nerve of wrist
  • Related ICD 10 COde
    ICD 10 Code S64.0

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    Related ICD 10 COde
    ICD 10 Code S65.0

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    Klumpke paralysis

    Klumpke paralysis that occurs when the nerve is torn from the spinal cord.
    Related ICD 10 COde
    ICD 10 Code P14.1

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    Related ICD 10 COde
    ICD 10 Code G57.3

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    Related ICD 10 COde
    ICD 10 Code G57.2

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    Related ICD 10 COde
    ICD 10 Code G57.6

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    Related ICD 10 COde
    ICD 10 Code G56.3

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    Related ICD 10 COde
    ICD 10 Code G57.4

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    Related ICD 10 COde
    ICD 10 Code G56.2

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    Related ICD 10 COde
    ICD 10 Code G54.1

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    Related ICD 10 COde
    ICD 10 Code C47

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    Abbreviated Terms

  • sympathetic and parasympathetic nerves and ganglia
  • Related ICD 10 COde
    ICD 10 Code C47

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    Related ICD 10 COde
    ICD 10 Code G57

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    Related ICD 10 COde
    ICD 10 Code G56.1

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    Mononeuropathy

    Damage to a single nerve or nerve group of the upper limb (not including central nervous structures such as the brain, brainstem or spinal cord), resulting in a loss of movement, sensation and/or autonomic function)

    Additional Information

    Upper limb mononeuropathy refers to pathology affecting a single peripheral nerve of the upper limb. The peripheral nerve may be damaged anywhere along its course from the spinal nerve root, as part of the brachial plexus, or along its terminal branches. Damage results in weakness, disturbance of sensation, and/or pain. Generally, the term mononeuropathy refers to nerve damage occurring distal to the brachial plexus. There are many nerves in the arm distal to the brachial plexus; therefore, different mononeuropathies can occur.

    Organ Affected

    Upper limb structure (body structure)|Entire upper limb (body structure)
    Related ICD 10 COde
    ICD 10 Code G56

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    Related ICD 10 COde
    ICD 10 Code G53

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    Neoplasms of spinal cord, cranial nerves or other parts of the central nervous system

    This is a tumor of cranial nerves having none of the characteristics of a malignant neoplasm.

    Abbreviated Terms

  • benign neoplasm of abducens nerve
  • benign neoplasm of accessory nerve
  • benign neoplasm of facial nerve
  • benign neoplasm of glossopharyngeal nerve
  • benign neoplasm of hypoglossal nerve
  • benign neoplasm of oculomotor nerve
  • benign neoplasm of olfactory nerve
  • benign neoplasm of optic nerve
  • benign neoplasm of trigeminal nerve
  • benign neoplasm of trochlear nerve
  • benign neoplasm of vagus nerve
  • benign tumour of optic nerve
  • neuroma of optic nerve
  • neurinoma of unspecified site
  • acoustic neuroma
  • Related ICD 10 COde
    ICD 10 Code D33.3

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    Related ICD 10 COde
    ICD 10 Code G54.8

    ----------------------

    Related ICD 10 COde
    ICD 10 Code G54

    ----------------------

    Related ICD 10 COde
    ICD 10 Code G61

    ----------------------

    Abbreviated Terms

  • idiopathic progressive polyneuropathy
  • progressive peripheral paresis
  • Related ICD 10 COde
    ICD 10 Code G60.3

    ----------------------

    Also Known As

  • radiation-induced polyneuropathy
  • Related ICD 10 COde
    ICD 10 Code G62.8

    ----------------------

    Related ICD 10 COde
    ICD 10 Code D36.1

    ----------------------

    Polyneuropathy

    Acquired inflammatory peripheral neuropathies are of a presumed immune etiology and are classified on the basis of their clinical course: acute inflammatory demyelinating polyneuropathy (AIDP or Guillain-Barr??? syndrome) with the motor deficit reaching a maximal level by 28 days, and chronic inflammatory demyelinating polyneuropathy (CIDP) which has a slowly progressive course of two or more months or a relapsing remitting course. There are many variants of AIDP and CIDP.

    Signs And Symptoms

  • Inflammation (qualifier value)
  • Inflammation (morphologic abnormality)
  • Organ Affected

    Nerve structure (body structure)|Entire nerve (body structure)
    Related ICD 10 COde
    ICD 10 Code G61

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    Symptoms, signs or clinical findings involving the skin

    A group of cutaneous symptoms for which it is frequently impossible to identify a precise cause.

    Organ Affected

    Skin structure (body structure)|Entire skin (body structure)
    Related ICD 10 COde
    ICD 10 Code R20

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    Syndromic conditions with disorders of intellectual development as a relevant clinical feature

    Giant axonal neuropathy (GAN) is a hereditary degenerative disorder that is characterised by a progressive motor and sensitive peripheral and central nervous system neuropathy.

    Also Known As

  • GAN - [Giant axonal neuropathy]
  • Related ICD 10 COde
    ICD 10 Code G60

    ----------------------

    Toxic neuropathy

    This is a nerve disorder affecting multiple peripheral nerves simultaneously, which is due to the toxicity of medications.

    Organ Affected

    Nerve structure (body structure)|Entire nerve (body structure)

    Causes

    Drug or medicament (substance)|Pharmaceutical / biologic product (product)

    Also Known As

  • drug-related polyneuropathy
  • polyneuropathy due to drug
  • Related ICD 10 COde
    ICD 10 Code G62.0

    ----------------------

    Abbreviated Terms

  • plexiform neurofibroma of unspecified site
  • melanotic neurofibroma of unspecified site
  • Related ICD 10 COde
    ICD 10 Code D36.1

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