Combined pituitary hormone deficiency
Combined pituitary hormone deficiency
Combined pituitary hormone deficiency is a condition that causes a shortage (deficiency) of several hormones produced by the pituitary gland, which is located at the base of the brain. A lack of these hormones may affect the development of many parts of the body. The first signs of this condition include a failure to grow at the expected rate and short stature that usually becomes apparent in early childhood.People with combined pituitary hormone deficiency may have hypothyroidism, which is underactivity of the butterfly-shaped thyroid gland in the lower neck. Hypothyroidism can cause many symptoms, including weight gain and fatigue. Other features of combined pituitary hormone deficiency include delayed or absent puberty and lack the ability to have biological children (infertility). The condition can also be associated with a deficiency of the hormone cortisol. Cortisol deficiency can impair the body's immune system, causing individuals to be more susceptible to infection.Rarely, people with combined pituitary hormone deficiency have intellectual disability; a short, stiff neck; or underdeveloped optic nerves, which carry visual information from the eyes to the brain.
Different Conditions
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Related ICD 10 COde
ICD 10 Code E23.0----------------------
Congenital hypogonadotropic hypogonadism
This is a condition which is characterized by hypogonadism due to an impaired secretion of gonadotropins, including follicle-stimulating hormone (FSH) and luteinizing hormone (LH), by the pituitary gland in the brain, and in turn decreased gonadotropin levels and a resultant lack of sex steroid production. This diagnosis is associated with other endocrinopathies.Related ICD 10 COde
ICD 10 Code E23.0----------------------
Genetic growth hormone deficiency
This refers to a x-linked intellectual deficit with an isolated condition, caused by problems arising in the pituitary gland, in which the body does not produce enough growth hormone (GH).Related ICD 10 COde
ICD 10 Code E23.0----------------------
Growth hormone deficiency with or without pituitary stalk interruption syndrome
This refers to an idiopathic condition, caused by problems arising in the pituitary gland, in which the body does not produce enough growth hormone (GH).Abbreviated Terms
Related ICD 10 COde
ICD 10 Code E23.0----------------------
Hypofunction or certain specified disorders of pituitary gland
A disorder manifesting a deficiency or decrease of one or more pituitary hormones, which is caused by a variety of diseases such as tumour, trauma/surgery, irradiation, inflammation and haemorrhage/infarction.Organ Affected
Pituitary structure (body structure)|Entire pituitary gland (body structure)Abbreviated Terms
Also Known As
Related ICD 10 COde
ICD 10 Code E23.0----------------------
Related ICD 10 COde
ICD 10 Code E23.0----------------------
Hypopituitarism
This refers to non-acquired decreased (hypo) secretion of one or more of the eight hormones normally produced by the pituitary gland at the base of the brain.Also Known As
Related ICD 10 COde
ICD 10 Code E23.0----------------------
Nonacquired combined hypopituitarism
A clinical status with impaired synthesis/secretion of all six anterior pituitary hormones caused by a variety of tumorous and non-tumorous diseases, manifesting i secondary hypoadrenocorticism, hypothyroidism, and hypognadotropic hypogonadism.Related ICD 10 COde
ICD 10 Code E23.0----------------------
Nonacquired hypopituitarism
A rare disorder of impaired synthesis/secretion of follicle-stimulating hormone (FSH) in the pituitary gland, manifesting in hypogonadotropic hypogonadism, usually caused by a mutation of FSH beta subunit gene.Also Known As
Related ICD 10 COde
ICD 10 Code E23.0----------------------
Nonacquired isolated growth hormone deficiency
This syndrome is characterised by growth retardation and short stature (despite the presence of normal or slightly elevated levels of immunoreactive growth hormone, GH), low concentrations of insulin-like growth factor-I (IGF-I) and a significant increase in growth rate following recombinant GH therapy. Prevalence is unknown but only a few cases have been reported in the literature. The syndrome is caused by various mutations in the GH1 gene (17q22-q24) that result in structural GH anomalies and a biologically inactive molecule. Transmission is autosomal recessive.Also Known As
Related ICD 10 COde
ICD 10 Code E23.0----------------------
Short stature due to a defect in growth hormone receptor or post-receptor pathway
Laron syndrome with immunodeficiency is characterized by severe post-natal growth retardation, delayed bone age and facial dysmorphism (prominent forehead, hypoplastic nasal bridge), and low serum IGF-1 concentrations with normal or high GH concentrations, associated with immunodeficiency haracterized by moderate lymphopenia which leads to recurrent infections of the skin and respiratory tract.Additional Information
This syndrome is characterized by severe growth retardation associated with immunodeficiency. Less than 10 cases have been described in literature. The patients present typical clinical and biochemical features of Laron syndrome such as post-natal growth retardation, delayed bone age and facial dysmorphism (prominent forehead, hypoplastic nasal bridge), and low serum IGF-1 concentrations with normal or high GH concentrations. Immunodeficiency is characterized by moderate lymphopenia which leads to recurrent infections of the skin and respiratory tract. Severe chronic lung disease, chronic diarrhea, juvenile idiopathic arthritis (see these terms), generalized eczema, pulmonary infections and respiratory distress have already been described. The syndrome is due to mutation in the signal transducer and activator of transcription 5b gene (STAT5b). Transmission is autosomal recessive. There have been reports of STAT5b mutations resulting in Laron symptoms but not associated with immunodeficiency.Related ICD 10 COde
ICD 10 Code E23.0----------------------